We offer a position as biotechnician in development of in vivo gene therapy with a focus on the nervous system within UMC Utrecht. To this end, you will work in a division overarching team that strives to accelerate clinical development of gene therapies by focusing on one of the current main obstacles in this field: efficient delivery of gene products to the right organs and cell types of interest (by designing minimal promoters and enhancers, specific coat proteins). Your role is to grow high titer AAV stocks, deliver these and other gene delivery methods to mice and test the efficacy of gene delivery in vivo using FACS sorting and immunohistochemistry.
The position is embedded within the Department of Translational Neuroscience of UMC Utrecht. The project focusses on building an in-house viral vector production platform within UMC Utrecht to support development of gene therapy. In addition to this embedding, the technician will be team member of the UMCU gene-therapy delivery platform and thus closely collaborate with the other UMC Utrecht groups working on gene therapies, in particular with Innovation Center for Advanced Therapies (ICAT) and Regenerative Medicine Center Utrecht (RMCU).
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