We offer a temporary position for a postdoctoral researcher for a period of 1 to 2 years. As a Postdoc, you will participate in dissecting the molecular mechanisms of how metabolism regulate (stem) cell fate decisions during tumor development, development and regeneration. This project includes the use of organoids, fluorescent-based live imaging, bulk and single cell-OMICS analysis and common molecular biology and biochemistry lab technics.
The Rodriguez Colman Lab offers an international atmosphere with a strong sense of teamwork. We focus on defining how metabolism supports and regulates intestinal development, regeneration and tumorigenesis. “We are what we eat”. The intestine is the surface of absorption of nutrients; hence, intestinal cells are continuously stimulated by different species and concentrations of metabolites. However, how these metabolic inputs directly impact on (stem) cell differentiation and function remains ill defined. Interestingly, this is also true in cancer. Metabolic reprogramming is one of the hallmarks of cancer, but how this derailed metabolic state affects cancer stem cell fate and tumor development is unclear. Our research aims to define how diet determines intestinal health, tumor development and chemotherapy response. More information can be found at www.RodriguezColmanLab.org
We are looking for a highly motivated and skilled Postdoc with a background in metabolism, cancer, cell biology and molecular biology. Experience with organoids, bioinformatics, imaging analysis and a solid publication record are preferred. The ideal candidate is motivated, goal-oriented, and collaborative. Independence and the ability to think critically are expected.
It is also expected that the Postdoc has scientific curiosity is goal-oriented and collaborative. Working independently and having the ability to think critically is important.